@article{67571, keywords = {Animals, Oxygen, Macaca mulatta, Photic Stimulation, Statistics as Topic, Brain, Neural Pathways, Brain Mapping, Magnetic Resonance Imaging, Image Processing, Computer-Assisted, Rest, Electroencephalography, Fixation, Ocular, Anesthesia, Brain Waves}, author = {Liang Wang and Yuri Saalmann and Mark Pinsk and Michael Arcaro and Sabine Kastner}, title = {Electrophysiological low-frequency coherence and cross-frequency coupling contribute to BOLD connectivity.}, abstract = { Brain networks are commonly defined using correlations between blood oxygen level-dependent (BOLD) signals in different brain areas. Although evidence suggests that gamma-band (30-100~Hz) neural activity contributes to local BOLD signals, the neural basis of interareal BOLD correlations is unclear. We first defined a visual network in monkeys based on converging evidence from interareal BOLD correlations during a fixation task, task-free state, and anesthesia, and then simultaneously recorded local field potentials (LFPs) from the same four network areas in the task-free state. Low-frequency oscillations (\<20~Hz), and not gamma activity, predominantly contributed to interareal BOLD correlations. The low-frequency oscillations also influenced local processing by modulating gamma activity within individual areas. We suggest that such cross-frequency coupling links local BOLD signals to BOLD correlations across distributed networks. }, year = {2012}, journal = {Neuron}, volume = {76}, pages = {1010-20}, month = {12/2012}, issn = {1097-4199}, doi = {10.1016/j.neuron.2012.09.033}, language = {eng}, }